by Daniel G.S. Capelluto (2013)
Lipids are no longer seen as molecules that only provide membrane structure and organization. Due to their amphipathic nature, lipids are localized both on the surface and internally in membranes in the cell, and at these locations, trigger signaling pathways by interacting with soluble proteins, typically through lipid-interacting domains and motifs. More importantly, interconversion of lipid species in these compartments is fundamental, not only by sustaining signaling but also by contributing to signaling pathways that link protein receptors with intracellular effectors. With contributions from eleven leading research teams, this book updates the most recent findings associated with lipid-mediated cell signaling in mammals and plants. Contributors give comprehensive overviews of the physiological role of sphingolipids and phospholipids and how they undergo synthesis and turnover. Emphasis on the structural aspects of protein-lipid interactions is compiled in several chapters with great detail, whereas fully described mechanisms of lipid-mediated membrane targeting and insertion are considered in others. Authors also discuss models and techniques used to characterize lipid-mediated membrane binding of proteins. In addition, several chapters highlight the correlation of abnormal intracellular levels of lipids with human diseases, thus, making this book a valuable resource for biochemists, biophysicists, cell biologists, and clinical scientists with interest in lipid-mediated signaling pathways.
Timothy J. Brown, Paul W. Mielke
Statistical Mining and Data Visualization in Atmospheric Sciences brings together in one place important contributions and up-to-date research results in this fast moving area. Statistical Mining and Data Visualization in Atmospheric Sciences serves as an excellent reference, providing insight into some of the most challenging research issues in the field.
[written by Richard Walker
Text and colorful illustrations introduce the make up of the human body with cutaway drawings and explanations of the functions of the various body parts.
Ingolf Bernhardt, J. Clive Ellory
This book describes our current understanding of the transport of ions, amino acids, nucleosides, sugars, water and gases across the red blood cell membrane. It also outlines the necessary theoretical background to understand the dynamics of membrane constituents together with the mechanisms of transport pathways (pumps, channels, carriers/cotransporters, residual passive permeability). Separate chapters describe our present ideas about membrane and metabolic disorders as well as red blood cell diseases like malaria, sickle cell disease, and hypertension. The latest findings are explained on the basis of a historical review and well-established principles. The book and its chapters are thus structured in a manner that makes the material accessible to beginners in the field of red blood cell physiology and biophysics. Active researchers will also benefit from this carefully organized compilation.
Horst Rauchfuss, Terence N. Mitchell
"Up to now, we do not have a generally accepted theory about the origin of life and about the process of development of life, we only have a great number of - to some extent even contradictory - hypotheses. Meanwhile there came up some scientific findings beyond thought only a few years ago. Horst Rauchfuss is comparing the different theories from the view of the latest results and is giving an exciting and easy understandable insight into the present state of research."--BOOK JACKET.