Methods in Pharmacology

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Ingolf Bernhardt, J. Clive Ellory

This book describes our current understanding of the transport of ions, amino acids, nucleosides, sugars, water and gases across the red blood cell membrane. It also outlines the necessary theoretical background to understand the dynamics of membrane constituents together with the mechanisms of transport pathways (pumps, channels, carriers/cotransporters, residual passive permeability). Separate chapters describe our present ideas about membrane and metabolic disorders as well as red blood cell diseases like malaria, sickle cell disease, and hypertension. The latest findings are explained on the basis of a historical review and well-established principles. The book and its chapters are thus structured in a manner that makes the material accessible to beginners in the field of red blood cell physiology and biophysics. Active researchers will also benefit from this carefully organized compilation.

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Deepak Chopra

From Deepak Chopra, eminent physician and bestselling author, Restful Sleep gives help and advice on how to deal with sleep-related problems and enjoy perfect sleepNow available in b format RESTFUL SLEEP shows you how to: Fall asleep easily, without trying. Feel rested when you wake up. Avoid sleeping pills and other drugs. Identify and eliminate the imbalances causing your insomnia. Deal effectively with overactive thinking at bedtime. Achieve a healthy balance of rest and activity in your life. In this programme, based on ancient principles of mind-body medicine, Deepak Chopra teaches you how to overcome sleep problems by getting in touch with nature's rhythms. Step by step you'll learn techniques to eliminate the underlying causes of insomnia - and create a balanced mind and body. As a result, you'll sleep deeply at night every night - without medication, giving your body the rest it needs to restore your natural vitality.

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Matthieu Simard

Alors qu'il reçoit Anouk en pleurs, qui lui avoue ne plus vouloir voir son père qui a manifestement abusé d'elle, Martin doit intervenir pour que Pavel puisse à nouveau s'autoguérir. Faisant libérer le père de l'adolescent russe, il permet aux deux immigrants d'organiser leur évasion, ce qui se termine par la prise en otage d'un employé du laboratoire. Mais Anouk, ayant accompagné Martin sur les lieux, est alors aussi prise dans le collimateur de Bourgeois ... Situant l'action dans un célèbre collège de Montréal du quartier Côte-des-Neiges, un onzième épisode provocateur et empreint d'émotions troubles, s'insérant dans un feuilleton de 13 épîtres aux accents fantastiques, évoquant les sentiments de solitude profonde puis d'amour naissant chez un garçon en proie au désespoir. La narration, très brève, à la première personne, entrecoupée de réflexions rédigées en italique au style direct, présage une série accessible, inspirée des romans graphiques de type manga dont la première illustration, en clair-obscur, établit l'atmosphère. Teintée d'une pointe de science-fiction qui lui procure tout son souffle, cette série hyperréaliste tiendra le lecteur en haleine, malgré le lourd poids qui pèse sur les épaules de son héros. [SDM].

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Miral Dizdaroglu and Ali Esat Karakaya

"Damage to DNA by both exogenous and endogenous sources is increasingly regarded as highly important in the initiation and progression of cancer and in the occurance of other pathological events. DNA damage caused by reactive oxygen-derived species, also called oxidative DNA damage, is most the frequent type encountered by aerobic cells. Mechanistic studies of carcinogenesis indicate an important role of this type of damage to DNA. There is also strong evidence to support the role of oxidative DNA damage in the aging process. DNA damage is opposed in vivo by repair systems. If not repaired, DNA damage may lead to detrimental biological consequences. Therefore, the repair of DNA damage is regarded as one of the essential events in all life forms. In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. A detailed knowledge of mechanisms of DNA damage and repair, and how individual repair enzymes function may lead to manipulation of DNA repair in cells and ultimately to an increase of the resistence of human cells to DNA-damaging agents. This volume covers the most recent devlopments in this research field and contains contributions from scientists working in the fields of biochemistry, molecular biology, enzymology, biomedical science, and radiation biology."--Pub. desc.