Bioinformatics

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Kunihiko Kaneko, Ichiro Tsuda

Chaos in science has always been a fascinating realm since it challenges the usual scientific approach of reductionism. While carefully distinguishing between complexity, holism, randomness, incompleteness, nondeterminism and stochastic behaviour the authors show that, although many aspects of chaos have been phenomenologically understood, most of its defining principles are still difficult to grasp and formulate. Demonstrating that chaos escapes all traditional methods of description, the authors set out to find new methods to deal with this phenomenon and illustrate their constructive approach with many examples from physics, biology and information technology. While maintaining a high level of rigour, an overly complicated mathematical apparatus is avoided in order to make this book accessible, beyond the specialist level, to a wider interdisciplinary readership.

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Marc Thiriet

<p>The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models. The resulting biomathematical models and corresponding simulation software can be incorporated into platforms developed in virtual physiology for improved understanding and training.<br><br>Reviews structure and function of major constituents of the circulatory and respiratory apparatus<br><br>Describes major cellular processes involved in signaling, interactions, and adaptive responses of physiological conduits<br><br>Integrates biology, chemistry, and physics for the multidisciplinary exploration and modeling of physiological flows<br><br>Focuses on mechanotransduction-induced regulation</p>

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[edited by] Andriani Daskalaki

"This book covers a wide range of applications in oral medicine and describes through applied research projects, important methods like 3D radiographic imaging, 2D and 3D finite element analysis, proteomic analysis, genomic analysis, oral human microbiom, computational biomodeling, molecular modeling, and computational biochemistry and biophysics"--Provided by publisher.

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Lubov T. Timchenko

Baylor College of Medicine, Houston, TX. Text provides a comprehensive overview of new data on several disorders associated with unstable mutations. Discusses molecular pathological processes that originate unstable mutations, inherited diseases associated with unstable mutations, and polyglutamine diseases.