by Susan M. Love, M.D (2015)
"This fully revised sixth edition explains the biology behind the clinical options. Whether a reader is at risk and interested in prevention, diagnosed and trying to prevent recurrence, or living with metastatic cancer and seeking ways to survive longer and better, Dr. Love provides the most expert and reassuring support. This revision discusses the new genetic tests, controversies regarding screening, and what you need to know about dense breasts. Dr. Love also reviews the most recent technologies, such as liquid biopsies (identifying tumor cells in blood), plus current findings on the timing of chemotherapy, male breast cancer, and exciting new immunological therapies, all in her unique explanatory style. In addition, she considers the collateral damage of treatment and explores the newer approaches to metastatic disease"--Back cover.
Sally M. Walker
American chestnut trees were once found far and wide in North America's eastern forests. They towered up to one hundred feet tall, providing food and shelter for people and animals alike. For many, life without the chestnut seemed unimaginable until disaster struck in the early 1900s.
Abdulmassih S. Iskandrian
Nuclear cardiac imaging refers to cardiac radiological diagnostic techniques performed with the aid of radiopharmaceuticals, which are perfused into the myocardium as markers. These imaging studies provide a wide range of information about the heart, including the contractility of the heart, the amount of blood supply to the heart and whether parts of the heart muscle are alive or dead. This is essential information for cardiologists, and nuclear imaging has become an increasingly important part of the cardiologist's armamentarium. Iskandrian's text has become a leading book in the field and the fourth edition will continue the tradition. The text is completely updated to reflect the many advances in the field, and, as a new feature, each chapter concludes with a Q&A session on important and difficult clinical issues.
Thompson Sarkodie-Gyan
Debilitating neuromuscular disorders and traumatic brain, spinal cord or peripheral injuries have a devastating effect on those who suffer from them. Written from an engineering perspective, and based on a course taught by the American Society of Mechanical Engineers, Neurorehabilitation Devices first helps the designer to better understand and formulate design, measurement and control systems for biomedical devices used in the treatment and recovery of people suffering from these disorders. Just some of the topics covered in this book are: methods to allow an amputee to control a powered artificial arm by means of electrical signals generated by contractions of muscles of the residual limb in combination with motor nerve activity from peripheral nerves, as well as the development of new technologies to use electrical stimulation to treat the hyperactive bladder, to electrically induce bowel movement and defecation, and to develop methods for selective stimulation of nerve fibres.
David H. Kirn, Ta-Chiang Liu, Steve H. Thorne
Since the first report of an engineered oncolytic virus, there has been a continuing and steady increase of interest in the field, and while bench research remains vital for the translation of research in this field, its success depends on breakthroughs in clinical studies. Oncolytic Viruses: Methods and Protocols describes the construction and purification of capsid-modified adenoviruses as well as oncolytic adenoviruses, presents protocols for many individual virus species including engineering and preparation of oncolytic HSV, propagation, purification, and in vivo testing of oncolytic VSV, details properties of oncolytic reovirus and NDV, and describes the generation and testing of next generation of oncolytic vaccinia virus. As the host immune system plays a critical role in determining efficacy of oncolytic viruses, two chapters are devoted to the study of immune response. Recent advances in stem cell research have led the field in two distinct directions: the use of stem cells as carrier vehicles for oncolytic viruses and the targeting of cancer stem cells. As such, the volume describes the use of explant tissue samples from patients to potentially provide useful information predicting responses prior to clinical translation. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Oncolytic Viruses: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies in an effort to further our knowledge of this essential and vital field.