by David H. Kirn, Ta-Chiang Liu, Steve H. Thorne (2012)
Since the first report of an engineered oncolytic virus, there has been a continuing and steady increase of interest in the field, and while bench research remains vital for the translation of research in this field, its success depends on breakthroughs in clinical studies. Oncolytic Viruses: Methods and Protocols describes the construction and purification of capsid-modified adenoviruses as well as oncolytic adenoviruses, presents protocols for many individual virus species including engineering and preparation of oncolytic HSV, propagation, purification, and in vivo testing of oncolytic VSV, details properties of oncolytic reovirus and NDV, and describes the generation and testing of next generation of oncolytic vaccinia virus. As the host immune system plays a critical role in determining efficacy of oncolytic viruses, two chapters are devoted to the study of immune response. Recent advances in stem cell research have led the field in two distinct directions: the use of stem cells as carrier vehicles for oncolytic viruses and the targeting of cancer stem cells. As such, the volume describes the use of explant tissue samples from patients to potentially provide useful information predicting responses prior to clinical translation. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Oncolytic Viruses: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies in an effort to further our knowledge of this essential and vital field.
Guy R. Newell and Waun Ki Hong
New approaches to basic research, and the success of various chemotherapies for cancer of the aerodigestive tract, are among the topics of the 20 papers, from a February 1991 conference in Houston. Risk factors such as alcohol, smokeless tobacco, and asbestos, are considered, as are possible methods of prevention suggested by current chemotherapy, and epidemiological studies of vitamin A intake.
Harshawardhan Bal and Johnny Hujol
"The science and practice of medicine has undergone a fundamental change as a result of large-scale genome projects that led to the sequencing of a number of important microbial, plant and animal genomes in the last 5 years. This book aims to combine industry standard software engineering and design principles, genomics and bioinformatics and cancer research. It focuses on creating and integrating practical, useful tools for the scientific community in the context of real-life, real-value biomedical problems that researchers face on a routine basis, rather than being just a didactic exercise in learning a programming platform. The book leverages technologies for molecular biology, genomics and bioinformatics and cancer research developed by the NIH, NCI-Center for Bioinformatics (NCICB), the National Center for Biotechnology Information (NCBI, a division of the National Library of Medicine (NLM) at the NIH) and Stanford University."--Publisher.
Susan M. Love, M.D
"This fully revised sixth edition explains the biology behind the clinical options. Whether a reader is at risk and interested in prevention, diagnosed and trying to prevent recurrence, or living with metastatic cancer and seeking ways to survive longer and better, Dr. Love provides the most expert and reassuring support. This revision discusses the new genetic tests, controversies regarding screening, and what you need to know about dense breasts. Dr. Love also reviews the most recent technologies, such as liquid biopsies (identifying tumor cells in blood), plus current findings on the timing of chemotherapy, male breast cancer, and exciting new immunological therapies, all in her unique explanatory style. In addition, she considers the collateral damage of treatment and explores the newer approaches to metastatic disease"--Back cover.
[edited by] Darrell S. Rigel ... [et al
Skin cancer is a rapidly growing epidemic, and a condition that is highly treatable if detected early. This resource provides comprehensive guidance on all aspects of skin cancer, from undelying biology to clinical manifestations of disease, diagnosis, and treatment. The CD-ROM features illustrations from the text which can be used as slide presentations.