INTEGRATED MEDICINE (Volume II of A Companion To The Life Sciences)

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M.A. Hayat

"In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases suchas breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M.A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor"--Publisher's description.

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Justin Healey

Tobacco smoking kills up to half of its users and has a global annual death toll of more than five million people. It is the largest cause of preventable death in the western world. Around 3 million Australians are daily smokers, many of whom are socially disadvantaged. This title reveals the toxic contents of tobacco and the health effects of smoking (including passive smoking) on the body. The book also addresses a number of commonly held myths and misconceptions about the risks and impacts of smoking. A range of different quitting methods and products for overcoming nicotine addiction is al.

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Sunil R. Lakhani ... [et al

This new edition is a straightforward introduction to pathology and the mechanisms of disease. It puts pathology into its historical, scientific and clinical context for all medical, dental and nursing students and other health professionals.

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James H. Thorp, D. Christopher Rogers

The Field Guide to Freshwater Invertebrates of North America focuses on freshwater invertebrates that can be identified using at most an inexpensive magnifying glass. This Guide will be useful for experienced nature enthusiasts, students doing aquatic field projects, and anglers looking for the best fish bait, lure, or fly. Color photographs and art, as well as the broad geographic coverage, set this guide apart. 362 color photographs and detailed descriptions aid in the identification of species Introductory chapters instruct reader on how to use book, different inland water habitats and basic ecological relationships of freshwater invertebrates Broad taxonomic coverage is more comprehensive than any guide currently available.