Cover of Tumor dormancy, quiescence, and senescence
Read Time: ~5.3 hr

Tumor dormancy, quiescence, and senescence

by M.A. Hayat (2014)

About this book

"In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases suchas breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M.A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor"--Publisher's description.

Setting / LocationGlobal
Story EraModern Era
Protagonist / CoreTumor dormancy, quiescence, and senescence Lead Character

Readers who enjoyed this also loved

Cover of Living Time

Living Time

Bernadine Healy

This book is a personal odyssey, an intimate doctor-patient communication, and a prescriptive guide for patients and their families. Dr. Healy shares the insights that transformed her own struggle with a deadly cancer more than seven years ago, affirming her identity as patient and doctor. Medical advances have brought us to a turning point in the war on cancer. This quiet revolution is curing a growing number of cancers and transforming many others from a death sentence to a chronic illness, one that calls for vigilance but not despair. Beginning with her own story, Dr. Healy interweaves it with a lucid narrative of what cancer is, how it works, and how we can defeat it. She explains how new approaches are radically altering diagnosis and treatment, and offers ways for patients and their families to access the information and support they need to secure the best care.--From publisher description.

Cover of Step-up to medicine

Step-up to medicine

Steven S. Agabegi, Elizabeth D. Agabegi

This book is a primary review tool to prepare students for both the internal medicine clerkship and the end-rotation NBME shelf examination. This logical alternative to several limited-focus books blends a bullet-outline format students prefer in a review book with comprehensive paragraphs, as needed, for optimal preparation. Illustrations, charts, tables, graphs, mnemonics, and "Quick Hits" pearls for the clerkship speed and supplement learning. Ample content without superfluous detail enables students to readily evaluate and expand their knowledge of cardiology, pulmonary medicine, gastroenterology, hematology, neurology, endocrinology, rheumatology, nephrology, genitourinary disorders, fluids and electrolytes, dermatology, and musculoskeletal problems. A new section in this Second Edition presents 100 USMLE-style clinical vignette-based questions with answers. A color insert contains over thirty full-color images. A companion Website will offer the fully searchable text and color photographs.

Cover of Manmade

Manmade

Chris Salgardo, President, Kiehl's since

"Chris Salgardo, the charismatic president of cult-favorite skin-care line Kiehl's, delivers the definitive guide to grooming every man needs--and was afraid to ask for. Manmade is the first grooming and skin-care guide created with a 21st-century man in mind. Rather than dispense one-size-fits-all advice, style icon and Kiehl's prez Chris Salgardo tailors his guidance to a man's lifestyle and interest level, devoting chapters to the specific grooming needs of the polished gentleman; the extreme sports enthusiast; the bad boy/rebel; the artistic renaissance man; and the DIY hipster. From battling the effects of aging to hair concerns--whether too much or not enough--Chris offers insiders' secrets for looking impeccably (but not obviously) groomed"--

Cover of Diabetes for dummies

Diabetes for dummies

por el Dr. Alan L. Rubin

Covers the latest glucose meters and insulin treatments The straight facts on treating diabetes successfully and living a full life Want to know how to manage diabetes? Leading diabetes expert Dr. Alan Rubin gives you reassuring, authoritative guidance in putting together a state-of-the-art treatment program. You'll learn about all the advances in monitoring glucose, the latest medications, and how to develop a diet and exercise plan to stay healthy. You'll also see how to overcome insurance and on-the-job obstacles. Discover how to: Reduce your diabetes risk Understand the different types of diabetes Manage diabetes in children and the elderly Prevent long-term complications Get the support you need

Tumor dormancy, quiescence, and senescence by M.A. Hayat | Literally Just Books