Functional genomics--the deconstruction of the genome to determine the biological function of genes and gene interactions--is one of the most fruitful new areas of biology. The growing use of DNA microarrays allows researchers to assess the expression of tens of thousands of genes at a time. This quantitative change has led to qualitative progress in our ability to understand regulatory processes at the cellular level.This book provides a systematic introduction to the use of DNA microarrays as an investigative tool for functional genomics. The presentation is appropriate for readers from biology or bioinformatics. After presenting a framework for the design of microarray-driven functional genomics experiments, the book discusses the foundations for analyzing microarray data sets, genomic data-mining, the creation of standardized nomenclature and data models, clinical applications of functional genomics research, and the future of functional genomics.
Setting / LocationGlobal
Story EraContemporary / Future
Protagonist / CoreMicroarrays for an integrative genomics Lead Character
"There are fundamental principles for problem analysis and algorithm design that are continuously used in bioinformatics. This book concentrates on a clear presentation of these principles, presenting them in a self-contained, mathematically clear and precise manner, and illustrating them with lots of case studies from main fields of bioinformatics. Emphasis is laid on algorithmic "pearls" of bioinformatics, showing that things may get rather simple when taking a proper view into them. The book closes with a thorough bibliography, ranging from classic research results to very recent findings, providing many pointers for future research. Overall, this volume is ideally suited for a senior undergraduate or graduate course on bioinformatics, with a strong focus on its mathematical and computer science background."--Jacket.
This book aims to present modern thinking and developments in the theory, computation and experimental measurement of boundary layers, with particular emphasis on separation. Boundary-layer separation is a common occurrence in external and internal fluid flows at medium to high Reynolds numbers, and the understanding of the phenomenon has increased greatly in recent years. This book, bringing together contributions from theoreticians, computationalists and experimentalists, is an attempt to reflect much of the recent progress as well as point out future goals and provide ideas and stimulation. The work covers the effects of incompressibility and compressibility, steadiness and unsteadiness, two - and three - dimensionality, small - and large - scale behaviour, and various theories, computational methods and experimental findings, for laminar, transitional and turbulent separating flows.
FUEL YOUR EVIL URGES WHILE YOU BUILD GREEN ENERGY PROJECTS!Go green as you amass power! Fuel Cell Projects for the Evil Genius broadens your knowledge of this important, rapidly developing technology and shows you how to build practical, environmentally conscious projects using the three most popular and widely accessible fuel cells!In Fuel Cell Projects for the Evil Genius, high-tech guru Gavin Harper gives you everything you need to conduct practical experiments and build energizing fuel cell projects. You'll find complete, easy-to-follow plans that feature clear diagrams and schematics, as well as:Instructions for fascinating sustainable energy projects, complete with 180 how-to illustrationsExplanations of how fuel cells work and why the hydrogen economy will impact our lives in the near futureFrustration-factor removal-all the needed parts are listed, along with sourcesScience fair project ideas that are on the cutting edge of the latest technological developmentsFuel Cell Projects for the Evil Genius gives you complete plans, instructions, parts lists, and sources to:Understand how hydrogen could meet our energy needs in a post-carbon economyBuild a fuel cell car to race against your friendsBuild an intelligent fuel cell car which autonomously drivesBuild a simple fuel cell using adhesive bandagesHydrogen fuel your iPodHave a hydrogen barbecue-cook your food with zero carbon emissions!Discover how the amounts of hydrogen supplied to fuel cells affect the amounts of electricity producedAnd much more!
This landmark 1971 classic is reprinted with a new preface, chapter-by-chapter commentary, and straight-from-the-heart observations on topics that affect the professional life of programmers. Long regarded as one of the first books to pioneer a people-oriented approach to computing, The Psychology of Computer Programming endures as a penetrating analysis of the intelligence, skill, teamwork, and problem-solving power of the computer programmer. Finding the chapters strikingly relevant to today's issues in programming, Gerald M. Weinberg adds new insights and highlights the similarities and differences between now and then. Using a conversational style that invites the reader to join him, Weinberg reunites with some of his most insightful writings on the human side of software engineering. Topics include egoless programming, intelligence, psychological measurement, personality factors, motivation, training, social problems on large projects, problem-solving ability, programming language design, team formation, the programming environment, and much more. The author says, "On an inspired eight-week vacation in Italy, I wrote the first draft of The Psychology of Computer Programming. . . . the book quickly became a best-seller among technical titles, running through more than twenty printings and staying in print for twenty-five years. . . . "For this Silver Anniversary Edition, I decided to take my own advice and not try to hide my errors, for they would be the source of the most learning for my readers. I decided to leave the original text as it was—antiques and all—for your illumination, and simply to add some 'wisdom of hindsight' remarks whenever the spirit moved me. I hope you find the perspective brought by this time-capsule contrast as useful to you as it has been to me." J.J. Hirschfelder of Computing Reviews wrote: "The Psychology of Computer Programming . . . was the first major book to address programming as an individual and team effort, and became a classic in the field. . . . Despite, or perhaps even because of, the perspective of 1971, this book remains a must-read for all software development managers." Sue Petersen of Visual Developer said: "In this new edition, Jerry looks at where we were 30 years ago, where we are now and where we might be in the future. Instead of changing the original text, he's added new comments to each chapter. This allows the reader to compare and contrast his thinking over the decades, showcasing the errors and omissions as well as the threads that bore fruit. ". . . one issue -- communication -- has been at the core of Jerry's work for decades. Unknown to him at the time, Psychology was to form the outline of his life's work. . . . Psychology is valuable as history in a field that is all too ready to repeat the errors of its past. Read Psychology as a picture of where we've been, where we are now, and where we need to go next. Read it as an index to the thinking of one of the most influential figures in our field."
Microarrays for an integrative genomics by Isaac S. Kohane, Alvin T. Kho, and Atul J. Butte | Literally Just Books
