Parallel Computation

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Miral Dizdaroglu and Ali Esat Karakaya

"Damage to DNA by both exogenous and endogenous sources is increasingly regarded as highly important in the initiation and progression of cancer and in the occurance of other pathological events. DNA damage caused by reactive oxygen-derived species, also called oxidative DNA damage, is most the frequent type encountered by aerobic cells. Mechanistic studies of carcinogenesis indicate an important role of this type of damage to DNA. There is also strong evidence to support the role of oxidative DNA damage in the aging process. DNA damage is opposed in vivo by repair systems. If not repaired, DNA damage may lead to detrimental biological consequences. Therefore, the repair of DNA damage is regarded as one of the essential events in all life forms. In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. A detailed knowledge of mechanisms of DNA damage and repair, and how individual repair enzymes function may lead to manipulation of DNA repair in cells and ultimately to an increase of the resistence of human cells to DNA-damaging agents. This volume covers the most recent devlopments in this research field and contains contributions from scientists working in the fields of biochemistry, molecular biology, enzymology, biomedical science, and radiation biology."--Pub. desc.

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Mark H. Holmes

<p>This introductory graduate text is based on a graduate course the author has taught repeatedly over the last twenty or so years to students in applied mathematics, engineering sciences, and physics. Each chapter begins with an introductory development involving ordinary differential equations, and goes on to cover more advanced topics such as systems and partial differential equations. Moreover, it also contains material arising from current research interest, including homogenisation, slender body theory, symbolic computing, and discrete equations. Many of the excellent exercises are derived from problems of up-to-date research and are drawn from a wide range of application areas.</p><p> For this new edition every section has been updated throughout, many only in minor ways, while others have been completely rewritten. New material has also been added. This includes approximations for weakly coupled oscillators, analysis of problems that involve transcendentally small terms, an expanded discussion of Kummer functions, and metastability. Two appendices have been added, one on solving difference equations and another on delay equations. Additional exercises have been included throughout.</p><p> Review of first edition:</p><p>"Those familiar with earlier expositions of singular perturbations for ordinary and partial differential equations will find many traditional gems freshly presented, as well as many new topics. Much of the excitement lies in the examples and the more than 250 exercises, which are guaranteed to provoke and challenge readers and learners with various backgrounds and levels of expertise."</p><p>(SIAM Review, 1996 )</p><p> </p><p>

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David Wescott ... [et al

"The official study guide for the Certified Wireless Analysis Professional certification from CWNP. Four leading wireless experts thoroughly prepare you for the vendor-neutral CWAP exam administered by CWNP, the industry leader for enterprise Wi-Fi training and certification. This official study guide not only covers all exam objectives for the CWAP exam, it also prepares you to administer and troubleshoot complex enterprise WLAN environments. Covers all exam objectives for the Certified Wireless Analysis Professional (CWAP) exam. Covers 802.11 physical (PHY) and 802.11 MAC layer frame formats and technologies. Also covers 802.11 operation and frame exchanges, spectrum analysis and troubleshooting, and protocol analysis and troubleshooting. Includes hands-on exercises using the Wireshark protocol analyzer and Fluke Network's Spectrum analyzer software. Companion CD includes two practice exams and over 150 electronic flashcards. Advancing your skills as a wireless administrator professional? Start by passing the CWAP exam with the complete test prep you'll find in this practical study guide and CD"--

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David H. Kirn, Ta-Chiang Liu, Steve H. Thorne

Since the first report of an engineered oncolytic virus, there has been a continuing and steady increase of interest in the field, and while bench research remains vital for the translation of research in this field, its success depends on breakthroughs in clinical studies. Oncolytic Viruses: Methods and Protocols describes the construction and purification of capsid-modified adenoviruses as well as oncolytic adenoviruses, presents protocols for many individual virus species including engineering and preparation of oncolytic HSV, propagation, purification, and in vivo testing of oncolytic VSV, details properties of oncolytic reovirus and NDV, and describes the generation and testing of next generation of oncolytic vaccinia virus. As the host immune system plays a critical role in determining efficacy of oncolytic viruses, two chapters are devoted to the study of immune response. Recent advances in stem cell research have led the field in two distinct directions: the use of stem cells as carrier vehicles for oncolytic viruses and the targeting of cancer stem cells. As such, the volume describes the use of explant tissue samples from patients to potentially provide useful information predicting responses prior to clinical translation. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Oncolytic Viruses: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies in an effort to further our knowledge of this essential and vital field.