Step-up to medicine

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Bernadine Healy

This book is a personal odyssey, an intimate doctor-patient communication, and a prescriptive guide for patients and their families. Dr. Healy shares the insights that transformed her own struggle with a deadly cancer more than seven years ago, affirming her identity as patient and doctor. Medical advances have brought us to a turning point in the war on cancer. This quiet revolution is curing a growing number of cancers and transforming many others from a death sentence to a chronic illness, one that calls for vigilance but not despair. Beginning with her own story, Dr. Healy interweaves it with a lucid narrative of what cancer is, how it works, and how we can defeat it. She explains how new approaches are radically altering diagnosis and treatment, and offers ways for patients and their families to access the information and support they need to secure the best care.--From publisher description.

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M.A. Hayat

"In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases suchas breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M.A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor"--Publisher's description.

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David J. Anschel

Completely revised and small enough to fit in a lab coat pocket, Neurology: PreTest Self Assessment and Review, 5/e features 500 questions, including 200 new in clinical vignette format, with answers and explanations. All questions are reviewed by recent USMLE Step 2 test-takers.Prepare Early...Score HigherPre-Test® is the medical student's most dynamic weapon for mastering the USMLE Step 2.Great for course review and clinical rotations, too! Neurology: PreTest® asks the right questions so you'll know the right answers. Open it and start learning what's on the test.PreTest® is the closest you can get to seeing the test before you take it.This one-of-a-kind test prep guide helps you:Get to know actual material on the examPractice with 500 multiple-choice questions, many with clinical vignettesBuild confidence, skills, and knowledgeLearn key factsFind references with every answerThere are plenty of answers out there. But only PreTest® delivers USMLE type questions, in USMLE format.Open this PreTest® for:Format that simulates the exam500 board-type questionsReferenced answers and explanationsMaterial reviewed by recent USMLE Step 2 test-takersSTUDENT TESTED AND REVIEWED"The strength of the questions in this book is in the cross-coverage of neurology with the other disciplines."—A medical student who recently passed the USMLE.

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J.A. Muir Gray

This book aims to help those people who have to make decisions about groups of patients and/or populations base such decisions on a careful appraisal of the best evidence available. The contents cover three main topics: (a) finding and appraising evidence; (b) developing the capacity of individuals and organisations to use evidence; and (c) implementation (getting research into practice).